International Agency for Research on Cancer (IARC) - Summaries & Evaluations
N-NITROSOPIPERIDINE
VOL.: 17 (1978) (p. 287)
CAS No.: 100-75-4
Chem. Abstr. Name: 1-Nitroso-piperidine
5. Summary of Data Reported and Evaluation
5.1 Experimental data
N-Nitrosopiperidine is carcinogenic in mice, rats, Syrian golden,
European and Chinese hamsters and monkeys after its administration by
oral and other routes. It produces benign and malignant tumours of the
liver, lung, forestomach and oesophagus in mice, of the liver,
oesophagus and respiratory system in rats, and of the upper digestive
tract, respiratory system and liver in hamsters; it produces
hepatocellular carcinomas in monkeys. It is carcinogenic in mice and
hamsters after its administration in single doses.
5.2 Human data
No case reports or epidemiological studies were available to the
Working Group. Available information on occurrence suggests that the
general population may be exposed sporadically to low levels of
N-nitrosopiperidine; however, no exposed group suitable for an
epidemiological investigation has yet been identified.
5.3 Evaluation
There is sufficient evidence of a carcinogenic effect of
N-nitrosopiperidine in several experimental animal species. Although
no epidemiological data were available, N-nitrosopiperidine should be
regarded for practical purposes as if it were carcinogenic to
humans.
Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)
For definition of terms, see Preamble Evaluation.
Synonyms
Last updated: 27 March 1998