International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 17 (1978) (p. 287)

CAS No.: 100-75-4
Chem. Abstr. Name: 1-Nitroso-piperidine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosopiperidine is carcinogenic in mice, rats, Syrian golden, European and Chinese hamsters and monkeys after its administration by oral and other routes. It produces benign and malignant tumours of the liver, lung, forestomach and oesophagus in mice, of the liver, oesophagus and respiratory system in rats, and of the upper digestive tract, respiratory system and liver in hamsters; it produces hepatocellular carcinomas in monkeys. It is carcinogenic in mice and hamsters after its administration in single doses.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. Available information on occurrence suggests that the general population may be exposed sporadically to low levels of N-nitrosopiperidine; however, no exposed group suitable for an epidemiological investigation has yet been identified.

5.3 Evaluation

There is sufficient evidence of a carcinogenic effect of N-nitrosopiperidine in several experimental animal species. Although no epidemiological data were available, N-nitrosopiperidine should be regarded for practical purposes as if it were carcinogenic to humans.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)

For definition of terms, see Preamble Evaluation.


Last updated: 27 March 1998

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