International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 17 (1978) (p. 313)

CAS No.: 930-55-2
Chem. Abstr. Name: 1-Nitrosopyrrolidine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

N-Nitrosopyrrolidine is carcinogenic in rats after its oral administration: it produces hepatocellular carcinomas. It also increases the incidence of lung adenomas in mice following its oral administration. A study in rats has been reported in which a dose-response relationship was established.

5.2 Human data

No case reports or epidemiological studies were available to the Working Group. Available information on occurrence suggests that the general population may be exposed to low levels of N-nitrosopyrrolidine; however, no exposed group suitable for an epidemiological investigation has yet been identified.

5.3 Evaluation

There is sufficient evidence of a carcinogenic effect of N-nitrosopyrrolidine in one experimental animal species. Although no epidemiological data were available, N-nitrosopyrrolidine should be regarded as if it were carcinogenic to humans.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 2B)

For definition of terms, see Preamble Evaluation.


Last updated: 27 March 1998

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