International Agency for Research on Cancer (IARC) - Summaries & Evaluations
STREPTOZOTOCIN
VOL.: 17 (1978) (p. 337)
CAS No.: 18883-66-4
Chem. Abstr. Name: 2-Deoxy-2{[methyl-nitrosoamino)carbonyl]amino}D-glucopyranose
4. Summary of Data Reported and Evaluation
4.1 Experimental data
Streptozotocin is carcinogenic in mice, rats and Syrian golden and
Chinese hamsters following its intravenous or intraperitoneal
administration. It produces benign and malignant tumours of the liver
and kidney and islet-cell tumours of the pancreas. It is carcinogenic
after its administration in single doses.
4.2 Human data
No adequate data on humans were available to the Working Group, but
the chemotherapeutic use of streptozotocin indicates the existence of
an exposed group.
4.3 Evaluation
There is sufficient evidence of a carcinogenic effect of
streptozotocin in several experimental animal species. Although no
epidemiological data were available (and efforts should be directed
toward this end), streptozotocin should be regarded for practical
purposes as it were carcinogenic to humans.
Previous evaluation: Vol. 4 (1974)
Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 2B)
For definition of terms, see Preamble Evaluation.
Synonyms
- 2-Deoxy-2-(3-methy1-3-nitrosoureido)-D-glucopyranose
- N-D-Glucosyl-(2)-N'-nitroso-N'-methylurea
- NSC 85998
- STR
- Streptozocin
- Streptozoticin
Last updated: 27 March 1998