International Agency for Research on Cancer (IARC) - Summaries & Evaluations
STYRENE, POLYSTYRENE AND STYRENE-BUTADIENE COPOLYMERS
VOL.: 19 (1979) (p. 231)
Styrene
CAS No.: 100-42-5
Chem. Abstr. Name: Ethenylbenzene
Polystyrene
CAS No.: 9003-53-6
Chem. Abstr. Name: Ethenylbenzene homopolymer
Styrene-butadiene copolymers
CAS No.: 9003-55-8
Chem. Abstr. Name: Ethenylbenzene polymer with 1,3-butadiene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Styrene was tested by oral administration to mothers and offspring of
two strains of mice and of one strain of rats. In one strain of mice,
high doses of styrene increased the incidence of lung tumours in
offspring. In the other strain, a lower dose of styrene slightly
increased the incidence of liver-cell tumours in male offspring. In
rats, the total incidence of tumours was not statistically different
in styrene-treated and control animals.
Styrene is mutagenic.
Subcutaneous implantation of polystyrene discs, rods, spheres or
powder in rats induced local sarcomas, the incidences of which varied
with the size and form of the implant.
No data on the carcinogenicity of styrene-butadiene copolymers were
available to the Working Group.
5.2 Human data
The extensive production of styrene and polystyrene and the widespread
use of the polymer and the copolymers derived from styrene for
consumer products and medical applications suggest that occupationally
and medically exposed groups may be identified for epidemiological
investigation. Extensive data on toxicity in workers and hygienic
measurements indicate that exposures do occur. Skin absorption of
styrene has been reported. The widespread occurrence of styrene in the
environment and the fact that in some countries styrene and some of
its polymers are approved as food additives and for use in
contact with food (e.g, disposable dinnerware and drinking glasses)
indicate that the general population is also exposed.
The only report that relates to possible human carcinogenicity of
styrene has methodological deficiencies: the population at risk was
not clearly defined and may have been exposed to a variety of
chemicals, such as benzene. No conclusion could be made concerning the
carcinogenicity of styrene.
No case reports or epidemiological studies with regard to the
carcinogenicity of polystyrene were available to the Working Group.
The case reports and epidemiological studies that concern the
carcinogenic effects of styrene-butadiene copolymers also have
limitations: the usual ones apply to the case reports; the
epidemiological studies involved small numbers of workers. However,
the collective nature of the findings, together with the similarity of
tumour types observed, clearly indicate the need for further studies.
5.3 Evaluation
Although no information is available on carcinogenicity in humans
attributable to styrene, its wide use and the facility with which it
can be absorbed by inhalation indicate that it may be possible to
carry out studies measuring both dose and cancer incidence in exposed
workers. The finding of chromosomal aberrations in workers exposed to
styrene further supports the need for epidemiological investigations.
Results from polystyrene implant studies in animals point to the need
for further investigations with regard to the polymer. Recent
epidemiological information on styrene-butadiene copolymer workers,
which indicates lymphato-haematopoeietic malignancies, clearly
requires elucidation by further studies.
Subsequent evaluations: Suppl. 7 (1987) (Polystyrene, p. 70: Group 3) (Styrene-butadiene copolymers, p. 72: Group 3);
Vol. 60 (1994) (Styrene)
For definition of Groups, see Preamble Evaluation.
Synonyms for Styrene
- Cinnamene
- Phenethylene
- Phenylethene
- Phenylethylene
- Styrol
- Styrole
- Styrolene
- Vinylbenzene
- Vinylbenzol
Synonyms for Polystyrene
- Afcolene
- Atactic polystyrene
- Bactolatex
- Bakelite SMD 3500
- BASF III
- BDH 29-790
- Bextrene XL 750
- Bicolastic A 75
- Bicolene H
- Bio-Beads S-X 2
- BP-KLP
- BSB-S 40
- Bustren
- Cadco 0115
- Carinex GP
- Copal Z
- Cosden 550
- Denka QP3
- Diarex 43G
- Dorvon
- Dow 360
- Dylark 250
- Dylene
- Dylite F 40
- 686E
- Edistir RB
- Esbrite
- Escorez 7404
- Estyrene 4-62
- FC-MY 5450
- FG 834
- Foster Grant 834
- Gedex
- 454H
- HF 10
- HH 102
- HHI 11
- Hi-Styrol
- Hostyren N
- HT 88
- HT 91-1
- IT 40
- K 525
- KB (polymer)
- KM
- KM (polymer)
- Koplen 2
- KR 2537
- Krasten 1.4
- Lacqren 506
- LS 061A
- Lustrex
- Lustrex H 77
- MX 4500
- 168N15
- NaPSt
- NBS 706
- N 4000V
- Oligostyrene
- Owispol GF
- Pelaspan 333
- Piccolastic
- Polyco 220NS
- Polyflex
- Polystrol D
- Polystyrene BW
- Polystyrene latex
- Polystyrol
- Printel's
- PRX 1195
- PS 1
- PSB-C
- PSB-S-E
- PS 454H:
- PSV-L
- PY 2763
- R 3
- Rexolite 1422
- Rhodolne
- S 173
- SB 475K
- SD 188
- Shell 300
- SMD 3500
- SPS 600
- SRM 705
- ST 90
- Sternite 30
- ST 30UL
- Styrafoil
- Styragel
- Styrene polymers
- Styrex C
- Styrocell PM
- Styrofan 2D
- Styroflex
- Styrofoam
- Styrolux
- Styron
- Styropian
- Styropor
- TC 3-30
- TGD 5161
- TMDE 6500
- Toporex 500
- Trolitul
- Trycite 1000
- Ubatol U 2001
- UCC 6863
- UP 1
- UPM
- Vestolen P 5232G
- Vestyron
- Vinamul N 710
- Vinylbenzene polymer
- Vinyl Products R 3612
Synonyms for Styrene-butadiene copolymers
- Afcolac B 101
- BASF 661
- 1,3-Butadiene-styrene copolymer
- Butadiene-styrene polymer
- 1,3-Butadiene-styrene polymer
- Butadiene-styrene resin
- Butakon 85-71
- Diarek 600
- Dienol S
- Dow 209
- Dow Latex 612
- Dowtex TL 612
- DST 50
- DST 75
- Duranit
- Duranit 40
- Edistir RB 268
- Goodrite 1800X73
- Histyrene S 6F
- Hycar LX 407
- K 55E
- KRO 1
- KRO 2
- Litex CA
- Lytron 5202
- Marbon 8000A
- Nipol 407
- Pharos 100.1
- Pliolite 151
- Polybutadienepolystyrene copolymer
- Polyco 2410
- Polyco 2415
- PS-SU2
- SBS
- SBS (block polymer)
- SBS copolymer
- SD 345 (polymer)
- S6F Histyrene resin
- SKS 85
- Soil stabilizer 661
- Solprene 300
- Styrene-1,3-butadiene copolymer
- Styrene-butadiene polymer
- Styrene polymer with 1,3-butadiene
- Synpol 1500
- Thermoplastic 125
- TR 201
- UP 1E
- Vestyron HI
Last updated: 30 March 1998