International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VINYL ACETATE, POLYVINYL ACETATE
AND POLYVINYL ALCOHOL
VOL.: 19 (1979) (p. 341)
Vinyl acetate
CAS No.: 108-05-4
Chem. Abstr. Name: Acetic acid ethenyl ester
Polyvinyl acetate
CAS No.: 9003-20-7
Chem. Abstr. Name: Acetic acid ethenyl ester homopolymer
Polyvinyl alcohol
CAS No.: 9002-89-5
Chem. Abstr. Name: Ethenol homopolymer
5. Summary of Data Reported and Evaluation
5.1 Experimental data
In the only study available, vinyl acetate was tested in rats by
inhalation exposure; it produced no evidence of carcinogenicity.
Vinyl acetate was non-mutagenic in the only test system used.
Subcutaneous or intraperitoneal implantation of polyvinyl acetate
powder in mice and rats did not result in local sarcomas. Subcutaneous
implantation of polyvinyl alcohol sponges in rats produced local
sarcomas, whereas negative results were obtained with polyvinyl
alcohol powder.
5.2 Human data
No case reports or epidemiological studies relating to the
carcinogenicity of either vinyl acetate or polyvinyl acetate were
available to the Working Group. One case of haemangiopericytoma was
reported in a man exposed to polyvinyl alcohol.
The high levels of production of vinyl acetate, polyvinyl acetate and
polyvinyl alcohol indicate that occupationally exposed groups could be
identified for epidemiological investigation. The widespread use of
polyvinyl acetate and polyvinyl alcohol in diverse applications
indicates that the general population is also exposed.
5.3 Evaluation
No case reports or epidemiological studies concerning vinyl acetate
were available to the Working Group. Animal studies involving
implantation of polyvinyl acetate and polyvinyl alcohol powder in rats
did not result in local sarcomas, whereas in similar experiments with
polyvinyl alcohol sponges, local sarcomas were produced. Both
polyvinyl acetate and polyvinyl alcohol have substantial commercial
applications. Further studies are required before an evaluation can be
made of the carcinogenicity of these compounds.
Subsequent evaluation: Suppl. 7 (1987) (Polyvinyl acetate, p. 70: Group 3) (Polyvinyl alcohol, p. 70: Group 3);
Vol. 63 (1995) (Vinyl acetate)
For definition of Groups, see Preamble Evaluation.
Synonyms for Vinyl acetate
- Acetic acid vinyl ester
- 1-Acetoxyethylene
- 2,4-Diisocyanatotoluene
- Vinyl A monomer
- VAc
- VyAc
Synonyms for Polyvinyl acetate
- Acetic acid vinyl ester polymers
- Asahisol 1527
- ASB 516
- AYAA
- AYAF
- AYJV
- Bakelite AYAA
- Bond CH 3
- Borden 2123
- Cemedine 196
- Cevian 380
- D 50
- D 50(polymer)
- DCA 70
- Duvilax
- Elvacet 81-900
- Emultex F
- En-Cor
- EP 1208
- Esnil P 18
- Everflex B
- Formvar 1285
- Gelva
- Gohensil E 50Y
- Kurare OM 100
- Lemac
- Meikatex 5000NG60
- Merckogel OR
- Merckogen 6000
- Mokotex D 2602
- Movinyl
- Movinyl 801
- Movinyl 50M
- Mowilith 30
- National 120-1207
- National Starch 1014
- NS 2842
- OM 100
- OR 1500
- P-170
- Pioloform F
- Plyamul 40-155
- Plyamul 40-350
- Polisol S-3
- Polyco 953
- Polyfox P 20
- Poly(vinylacetate)
- Protex
- PS 3h
- PVAE
- R 10688
- Resyn 25-1025
- Rhodopas
- RV 225-5B
- S-nyl-p 42
- Soloid
- Soviol
- SP 60
- SP 60 (ester)
- Toabond 2
- TS2
- Ucar 15
- UK 131
- V 501
- VA-0112
- Vinac ASB 10
- Vinalite D 50N
- Vinamul 9300
- Vinapol A 16
- Vinnapas B
- Vinyl acetate homopolymer
- Vinyl acetate polymer
- Vinyl acetate resin
- Vinylite AYAF
- Vinyl Products R 10688
- Winacet D
Synonyms for Polyvinyl Alcohol
- Poly(vinyl alcohol)
- PVA
- vinyl alcohol polymer
- Alcotex 88/05
- Alkotex
- Alvyl
- Aracet A-PV
- Cipoviol W 72
- Covol
- Elvanol
- EP 160
- Gelvatol
- GH 20
- GL 02
- GL 03
- GLO 5
- GM 14
- Gohsenol AH 22
- Kuralon VP
- Kurare Poval 120
- Lemol
- M 13/20
- Mowiol
- NH 18
- Polydesis
- Polysizer 173
- Polyvinol
- Polyviol
- Polyviol M 13/140
- Poval 117
- PVA 008
- PVS 4
- Resistoflex
- Rhodoviol
- Solvar
- Sumitex H 10
- Vibatex S
- Vinacol MH
- Vinalak
- Vinarol
- Vinavilol 2-98
- Vinnarol
- Vinol
- Vinylon Film 2000
Last updated: 30 March 1998