International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 21 (1979) (p. 139)

5. Summary of Data Reported and Evaluation

(N.B. - This section should be read in conjunction with the General Remarks on Sex Hormones and with the General Conclusions on Sex Hormones.)

5.1 Experimental data

Chlorotrianisene was tested in only one experiment in rats by oral administration. The data were insufficient to evaluate the carcinogenicity of this compound.

5.2 Human data

No case reports or epidemiological studies on chlorotrianisene alone were available to the Working Group. Case reports and epidemiological studies on steroid hormones used in oestrogen-progestin contraceptive preparations have been summarized in the section, 'Oestrogens and Progestins in Relation to Human Cancer'.

5.3 Evaluation

The available experimental data are insufficient to evaluate the carcinogenicity of chlorotrianisene in animals. Studies in humans strongly suggest that the administration of oestrogens is causally related to an increased incidence of endometrial carcinoma; there is no evidence that chlorotrianisene is different from other oestrogens in this respect.

Subsequent evaluation: Suppl. 7 (1987) (Nonsteroidal oestrogens)

Last updated: 6 April 1998

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