VOL.: 24 (1980) (p. 59)
In mice, the experiment involving intraperitoneal administration of dapsone could not be evaluated. The other two experiments did not provide evidence of carcinogenicity.
Dapsone and its acetylated metabolites were not mutagenic to Salmonella typhimurium. Attention is drawn to the absence of studies on the teratogenicity of this compound.
Several cases of cancer have been reported in patients with dermatitis herpetiformis treated with dapsone. There was no evidence of an increased rate of cancer in patients with leprosy, many of whom would also have been treated with the drug.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations Dapsone (PIM 167) Dapsone (IARC Summary & Evaluation, Supplement7, 1987)