International Agency for Research on Cancer (IARC) - Summaries & Evaluations
DIHYDROXYMETHYLFURATRIZINE
VOL.: 24 (1980) (p. 77)
CAS No.: 794-93-4
Chem. Abstr. Name: Methanol, {([6-[2-(5-nitro-2-furanyl)ethenyl]-1,2,4-triazin-3-yl]imino}bis-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Dihydroxymethylfuratrizine was tested alone in female rats by oral
administration. Although a few tumours of the small intestine were
observed in treated animals, there was no difference in overall tumour
incidence as compared with controls. Panfuran-S, a commercial
formulation which contains dihydroxymethylfuratrizine, was also tested
in male mice and male rats by oral administration; it induced benign
and malignant tumours of the forestomach and small intestine in
animals of both species and of the oesophagus in mice.
Attention is drawn to the absence of studies on the teratogenicity of
this compound.
5.2 Human data
Dihydroxymethylfuratrizine in the form of Panfuran-S has been used in
the past for treatment of acute gastrointestinal infections.
No case reports or epidemiological studies were available to the
Working Group.
5.3 Evaluation
There are insufficient data to evaluate the carcinogenicity of
dihydroxymethylfuratrizine alone in experimental animals. There is
sufficient evidence that Panfuran-S, a commercial formulation which
contains dihydroxymethylfuratrizine and several other compounds, is
carcinogenic in experimental animals.
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Dihydroxymethylfuratrizine - Group 3)
(p. 69: Panfuran-S (containing dihydroxymethylfuratrizine) - Group 2B)
For definition of terms, see Preamble Evaluation.
Synonyms for Dihydroxymethylfuratrizine
- 3-Bis(hydroxymethyl)amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazine
- Bis(hydroxymethyl)furatrizine
- Furatone
- Furatone-S
- {[6-2-(5-Nitro-2-furyl)vinyl]as-triazin-3-yl]-imino}dimethanol
- N-[6-(5-Nitrofurfurylidenemethyl)-1,2,4-triazin-3-yl]iminodimethanol
- Panfuran-S
Last updated: 7 April 1998