International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 24 (1980) (p. 125)

CAS No.: 3771-19-5
Chem. Abstr. Name: Propanoic acid, 2-methyl-2-[4-(1,2,3,4-tetrahydro-1-naphthalenyl)phenoxy]-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Nafenopin was tested in acatalasemic mice (a strain with an unstable catalase gene) and in male rats by oral administration: it produced hepatocellular carcinomas in both species. A low incidence of pancreatic tumours was also observed in rats.

It was not mutagenic in Salmonella typhimurium.

5.2 Human data

Nafenopin has been suggested for use as a hypolipidaemic agent.

No case reports or epidemiological studies were available to the Working Group.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity of nafenopin in experimental animals. For practical purposes, nafenopin should be regarded as if it presented a carcinogenic risk to humans.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 2B)

For definition of terms, see Preamble Evaluation.

Synonyms for Nafenopin

Last updated: 7 April 1998

    See Also:
       Toxicological Abbreviations