International Agency for Research on Cancer (IARC) - Summaries & Evaluations
PHENOXYBENZAMINE AND
PHENOXYBENZAMINE HYDROCHLORIDE
VOL.: 24 (1980) (p. 185)
Phenoxybenzamine
CAS No.: 59-96-1
Chem. Abstr. Name: Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-
Phenoxybenzamine hydrochloride
CAS No.: 63-92-3
Chem. Abstr. Name: Benzenemethanamine, N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Phenoxybenzamine was tested intraperitoneally in mice; it produced an
increased incidence of lung tumours.
Phenoxybenzamine hydrochloride was tested intraperitoneally in mice
and rats; it produced local peritoneal sarcomas in animals of both
sexes.
Attention is drawn to the absence of adequate studies on the
mutagenicity or teratogenicity of phenoxybenzamine or its
hydrochloride.
5.2 Human data
Phenoxybenzamine hydrochloride has limited use as an a-adrenergic
receptor blocking agent.
No case reports or epidemiological studies were available to the
Working Group.
5.3 Evaluation
There is sufficient evidence that phenoxybenzamine hydrochloride is
carcinogenic in experimental animals by intraperitoneal
administration. No data on humans were available.
Previous evaluation: Vol. 9 (1975)
Subsequent evaluation: Suppl. 7 (1987) (p. 70: Phenoxybenzamine hydrochloride - Group 2B)
For definition of terms, see Preamble Evaluation.
Synonyms for Phenoxybenzamine
- Bensylyte
- 2-N-Benzyl-2-chloroethylamino)-1-phenoxypropane
- Benzyl(2-chloroethyl)-(l-methyl-2-phenoxyethyl)amine
- N-Phenoxyisopropyl-N-benzyl-b-chloroethylamine
Synonyms for Phenoxybenzamine hydrochloride
- Bensylyt NEN
- 2-(N-Benzyl-2-chloroethylamino)-1-phenoxypropane hydrochloride
- Benzyl(2-chloroethyl) (1-methyl-2-phenoxyethyl)amine hydrochloride
- Benzylyt
- Blocadren
- Dibenylin
- Dibenyline
- Dibenzylene
- Dibenzyline
- Dibenzyran
- Fenoxybenzamin
- Phenoxybenzamine HCI
- N-Phenoxyisopropyl-N-benzyl-b-chloroethylamine hydrochloride
- SKF 688A
Last updated: 7 April 1998