International Agency for Research on Cancer (IARC) - Summaries & Evaluations
PROFLAVINE, PROFLAVINE DIHYDROCHLORIDE,
PROFLAVINE HEMISULPHATE AND
PROFLAVINE MONOHYDROCHLORIDE
VOL.: 24 (1980) (p. 195)
Proflavin
CAS No.: 92-62-6
Chem. Abstr. Name: 3,6-Acridinediamine
Proflavine dihydrochloride
CAS No.: 531-73-7
Chem. Abstr. Name: 3,6-Acridinediamine, dihydrochloride
Proflavine hemisulphate
CAS No.: 1811-28-5
Chem. Abstr. Name: 3,6-Acridinediamine, sulfate (2:1)
Proflavine monohydrochloride
CAS No.: 952-23-8
Chem. Abstr. Name: 3,6-Acridinediamine monohydrochloride
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Proflavine monohydrochloride, as the hemihydrate, was tested in mice
and rats by oral administration. Proflavine hemisulphate was tested in
mice by skin application, intradermal administration and subcutaneous
implantation. All tests were inadequate for evaluation.
Proflavine is mutagenic in viral and bacterial systems. It increased
the number of chromatid breaks and induced sister chromatid exchanges
in mammalian cells.
Attention is drawn to the absence of studies on the
teratogenicity of this compound.
5.2 Human data
Proflavine and its salts have limited use as topical disinfectants.
No case reports or epidemiological studies were available to the
Working Group.
5.3 Evaluation
The available experimental results were inadequate for an evaluation
of the carcinogenicity of proflavine in experimental animals, and no
data were available from human studies. However, in view of its
mutagenicity, confirmed in several experimental systems, further
studies on the carcinogenicity of this compound are warranted.
Subsequent evaluation: Suppl. 7 (1987) (p. 70: Proflavine salts - Group 3)
For definition of italicized terms, see Preamble Evaluation.
Synonyms for Proflavin
- 2,8-Diaminoacridinium
- 3,6-Diaminoacridinium
- 3,7-Diamino-5-aza-anthracene
- Isoflav base
- Proflavin
- Profoliol
- Profoliol-B
- Proformiphen
- Profundol
- Profura
- Progarmed
- Pro-Gen
- Progesic
Synonyms for Proflavine dihydrochloride
- 3,6-Diaminoacridine dihydrochloride
- 2,8-Diaminoacridinium chloride hydrochloride
- 3,6-Diaminoacridinium chloride hydrochloride
- Proflavin dihydrochloride
Synonyms for Proflavine hemisulphate
- 3,6-Acridinediamine sulphate
- 3,6-Diaminoacridine bisulphate
- 3,6-Diaminoacridine sulphate (1:1)
- 3,6-Diaminoacridinium monohydrogen sulphate
- 2,8-Diaminoacridinium sulphate
- Flavin sulphate
- Flavine
- Isoflav
- Neutral proflavine sulphate
- Pancridine
- Proflavin hemisulphate
- Proflavine sulphate
- Sanoflavin
Synonyms for Proflavine monohydrochloride
- 3,6-Diaminoacridine monohydrochloride
- 3,6-Diaminoacridinium chloride hydrochloride
- 2,8-Diaminoacridinium chloride monohydrochloride
- Proflavin monohydrochloride
Last updated: 7 April 1998