VOL.: 26 (1981) (p. 249)
6-Mercaptopurine and 6-mercaptopurine riboside were proven to cause embryolethality at doses nontoxic to the mother and to induce severe teratogenic effects in several animal species. 6-Mercaptopurine is mutagenic in bacteria and in mice. It also produces chromosomal aberrations in various mammalian cells, including human peripheral lymphocytes tested in culture.
It produces chromosomal aberrations in peripheral lymphocytes. No data were available to evaluate the mutagenic potential of the drug in humans. The available data are not sufficient to establish whether 6-mercaptopurine can induce a teratogenic effect.
A small number of case reports document the occurrence of acute nonlymphocytic leukaemia in patients who received 6-mercaptopurine for both non-neoplastic and neoplastic disorders. No epidemiological study was available to the Working Group.
On the basis of the available data, no evaluation could be made of the carcinogenic risk of 6-mercaptopurine to humans.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations Mercaptopurine, 6- (IARC Summary & Evaluation, Supplement7, 1987)