VOL.: 26 (1981) (p. 97)
No data were available to evaluate the teratogenic potential of bleomycin in animals. It is mutagenic in yeast and in Drosophila melanogaster. It induces chromosomal changes and increases in sister chromatid exchanges in various mammalian cells in culture. The drug also induced neoplastic transformation in a mouse cell line.
No data were available to evaluate the teratogenic potential of bleomycin in humans. Chromosomal changes were seen in bone-marrow cells and peripheral lymphocytes of patients treated with bleomycin alone. No data were available to evaluate its mutagenic potential in humans.
The development of acute nonlymphocytic leukaemia following the administration of bleomycin with multiple other cytotoxic agents has been described in patients with Hodgkin's disease or non-Hodgkin's lymphoma. In a small epidemiological study of short duration, no excess of subsequent neoplasms was observed in patients treated with a regimen consisting of bleomycin, adriamycin, vinblastine and dacarbazine.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations