VOL.: 26 (1981) (p. 293)
Prednisone can induce teratogenic effects (predominantly cleft palate) in rodents. The available data do not indicate that the agent produces mutations or chromosomal damage.
Use of prednisone during pregnancy may have a significant effect on reducing birth weight. The data are not sufficient to evaluate whether this drug can induce teratogenic effects in humans. There are no data available indicating that prednisone is mutagenic or clastogenic.
In view of its wide use, the many references to previous administration of prednisone in patients with cancer are to be expected by chance alone. There is no epidemiological evidence suggesting an etiological relationship between prednisone and neoplasia.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations Prednisone (IARC Summary & Evaluation, Supplement7, 1987)