International Agency for Research on Cancer (IARC) - Summaries & Evaluations
1,5-NAPHTHALENEDIAMINE
VOL.: 27 (1982) (p. 127)
CAS No.: 2243-62-1
Chem. Abstr. Name: 1,5-Naphthalenediamine
5. Summary of Data Reported and Evaluation
5.1 Experimental data
1,5-Naphthalenediamine (technical grade) was tested in one experiment
in mice and in one experiment in rats by dietary administration. It
produced adenomas of the thyroid in male mice and carcinomas and
adenomas of the thyroid and lungs and carcinomas of the liver in
female mice. The experiment in rats was inadequate for evaluation.
1,5-Naphthalenediamine (technical-grade) was mutagenic to Salmonella
typhimurium.
5.2 Human data
1,5-Naphthalenediamine has been produced commercially since at least
1957. Its use as an intermediate in the manufacture of
1,5-naphthalene diisocyanate and of dyes could result in occupational
exposure.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is limited evidence for the carcinogenicity of
1,5-naphthalenediamine in experimental animals.
No evaluation of the carcinogenicity of 1,5-naphthalenediamine to
humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)
Synonyms
- 1,5-Diaminonaphthalene
- 1,5-Naphthylenediamine
Last updated: 8 April 1998