International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 27 (1982) (p. 199)

CAS No.: 82-28-0
Chem. Abstr. Name: 9,10-Anthracenedione, 1-amino-2-methyl-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

1-Amino-2-methylanthraquinone (technical grade, maximum purity 68%) was tested in one experiment in mice and one experiment in rats by dietary administration. This material increased the incidence of hepatocellular carcinomas in rats of both sexes and of kidney adenomas and adenocarcinomas in males. The experiment in mice was inadequate for evaluation.

No data on the mutagenicity of this compound were available.

5.2 Human data

1-Amino-2-methylanthraquinone was first produced commercially in 1948. It has been used as a dye intermediate in the US and is still produced in commercial quantities in western Europe. Its continued production could lead to occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity in experimental animals of the material tested, which was technical-grade 1-amino-2-methylanthraquinone of low purity.

In view of the uncertain purity of the compound tested and in the absence of data on humans, no evaluation of the carcinogenicity of 1-amino-2-methylanthraquinone could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 57: Group 3)


Last updated: 8 April 1998

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