International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 27 (1982) (p. 191)

CAS No.: 117-79-3
Chem. Abstr. Name: 9,10-Anthracenedione, 2-amino-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

2-Aminoanthraquinone (technical grade of low purity) was tested in one experiment in mice and in one experiment in rats by dietary administration. It produced hepatocellular carcinomas in mice of both sexes and in male rats.

Purified 2-aminoanthraquinone was not mutagenic to Salmonella typhimurium.

5.2 Human data

2-Aminoanthraquinone has been produced commercially since at least 1921. Its use as an intermediate in the manufacture of dyes and pigments could result in occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity in experimental animals of the material tested, which was technical-grade 2-aminoanthraquinone of low purity.

In view of the uncertain purity of the compound tested and in the absence of data on humans, no evaluation of the carcinogenicity of 2-aminoanthraquinone could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 56: Group 3)


Last updated: 8 April 1998

    See Also:
       Toxicological Abbreviations