International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 27 (1982) (p. 141)

CAS No.: 15721-02-5
Chem. Abstr. Name: (1,1'-Biphenyl)-4,4'-diamine, 2,2',5,5'-tetrachloro-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

2,2',5,5'-Tetrachlorobenzidine (of unknown purity) was tested for carcinogenicity by dietary administration in mice and rats. The available data were insufficient for evaluation.

2,2',5,5'-Tetrachlorobenzidine was mutagenic to Salmonella typhimurium with metabolic activation.

5.2 Human data

2,2',5,5'-Tetrachlorobenzidine has been produced commercially since at least 1965. Its use as an intermediate in the manufacture of organic pigments could result in occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

The available data were inadequate for an evaluation of the carcinogenicity of 2,2',5,5'-tetrachlorobenzidine in experimental animals.

No evaluation of the carcinogenicity of this compound to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 3)


Last updated: 8 April 1998

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