International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 27 (1982) (p. 141)
CAS No.: 15721-02-5
Chem. Abstr. Name: (1,1'-Biphenyl)-4,4'-diamine, 2,2',5,5'-tetrachloro-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
2,2',5,5'-Tetrachlorobenzidine (of unknown purity) was tested for
carcinogenicity by dietary administration in mice and rats. The
available data were insufficient for evaluation.
2,2',5,5'-Tetrachlorobenzidine was mutagenic to Salmonella typhimurium
with metabolic activation.
5.2 Human data
2,2',5,5'-Tetrachlorobenzidine has been produced commercially since at
least 1965. Its use as an intermediate in the manufacture of organic
pigments could result in occupational exposure.
No case report or epidemiological study was available to the Working
The available data were inadequate for an evaluation of the
carcinogenicity of 2,2',5,5'-tetrachlorobenzidine in experimental
No evaluation of the carcinogenicity of this compound to humans could
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 3)
Last updated: 8 April 1998