International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 27 (1982) (p. 205)

CAS No.: 129-15-7
Chem. Abstr. Name: 9,10-Anthracenedione, 2-methyl-1-nitro-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

2-Methyl-1-nitroanthraquinone (of uncertain purity/impurity) was tested in one experiment in mice and one experiment in rats by dietary administration. It was carcinogenic in mice of both sexes, producing haemangiosarcomas, and in rats, producing hepatocellular carcinomas in males and subcutaneous fibromas in animals of both sexes.

2-Methyl-1-nitroanthraquinone was mutagenic to Salmonella typhimurium.

5.2 Human data

2-Methyl-1-nitroanthraquinone was first produced commercially in 1946. Its probable use as a dye intermediate could result in occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity in experimental animals of the material tested, which was 2-methyl-1-nitroanthraquinone of uncertain purity/impurity.

In view of the uncertain purity/impurity of the compound tested and in the absence of data on humans, no evaluation of the carcinogenicity of 2-methyl-1-nitroanthraquinone could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 2B)


Last updated: 8 April 1998

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