International Agency for Research on Cancer (IARC) - Summaries & Evaluations
2-METHYL-1-NITROANTHRAQUINONE
VOL.: 27 (1982) (p. 205)
CAS No.: 129-15-7
Chem. Abstr. Name: 9,10-Anthracenedione, 2-methyl-1-nitro-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
2-Methyl-1-nitroanthraquinone (of uncertain purity/impurity) was
tested in one experiment in mice and one experiment in rats by dietary
administration. It was carcinogenic in mice of both sexes, producing
haemangiosarcomas, and in rats, producing hepatocellular carcinomas in
males and subcutaneous fibromas in animals of both sexes.
2-Methyl-1-nitroanthraquinone was mutagenic to Salmonella typhimurium.
5.2 Human data
2-Methyl-1-nitroanthraquinone was first produced commercially in 1946.
Its probable use as a dye intermediate could result in occupational
exposure.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is sufficient evidence for the carcinogenicity in experimental
animals of the material tested, which was
2-methyl-1-nitroanthraquinone of uncertain purity/impurity.
In view of the uncertain purity/impurity of the compound tested and in
the absence of data on humans, no evaluation of the carcinogenicity of
2-methyl-1-nitroanthraquinone could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 2B)
Synonym
- 1-Nitro-2-methylanthraquinone
Last updated: 8 April 1998