International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 27 (1982) (p. 147)
CAS No.: 139-65-1
Chem. Abstr. Name: Benzenamine, 4,4'-thiobis-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
4,4'-Thiodianiline was tested adequately for carcinogenicity in one
experiment in mice and in one experiment in rats by dietary
administration. It was carcinogenic for animals of both sexes of both
species. In mice, it produced hepatocellular carcinomas and
carcinomas or adenomas of the thyroid gland in animals of both sexes.
In rats, it produced metastatic thyroid gland carcinomas in animals of
both sexes, hepatocellular carcinomas and ear-canal papillomas or
carcinomas in males and adenocarcinomas of the uterus in females.
4,4'-Thiodianiline was mutagenic to Salmonella typhimurium with
5.2 Human data
4,4'-Thiodianiline was first produced commercially in the early 1940s.
Its use as a dye intermediate could lead to occupational exposure.
No case report or epidemiological study was available to the Working
There is sufficient evidence for the carcinogenicity of
4,4'-thiodianiline in experimental animals.
In the absence of data on humans, 4,4'-thiodianiline should be
regarded, for practical purposes, as if it presented a carcinogenic
risk to humans.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 16 (1974)
Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 2B)
- 4,4'-Diaminodiphenyl sulphide
- para,para'-Diaminodiphenyl sulphide
- 4,4'-Diaminophenyl sulphide
Last updated: 8 April 1998