International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 27 (1982) (p. 147)

CAS No.: 139-65-1
Chem. Abstr. Name: Benzenamine, 4,4'-thiobis-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

4,4'-Thiodianiline was tested adequately for carcinogenicity in one experiment in mice and in one experiment in rats by dietary administration. It was carcinogenic for animals of both sexes of both species. In mice, it produced hepatocellular carcinomas and carcinomas or adenomas of the thyroid gland in animals of both sexes. In rats, it produced metastatic thyroid gland carcinomas in animals of both sexes, hepatocellular carcinomas and ear-canal papillomas or carcinomas in males and adenocarcinomas of the uterus in females.

4,4'-Thiodianiline was mutagenic to Salmonella typhimurium with metabolic activation.

5.2 Human data

4,4'-Thiodianiline was first produced commercially in the early 1940s. Its use as a dye intermediate could lead to occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity of 4,4'-thiodianiline in experimental animals.

In the absence of data on humans, 4,4'-thiodianiline should be regarded, for practical purposes, as if it presented a carcinogenic risk to humans.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 16 (1974)

Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 2B)


Last updated: 8 April 1998

    See Also:
       Toxicological Abbreviations
       Thiodianiline, 4,4'-  (IARC Summary & Evaluation, Volume 16, 1978)