International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 27 (1982) (p. 133)

CAS No.: 99-59-2
Chem. Abstr. Name: Benzenamine, 2-methoxy-5-nitro-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

5-Nitro-ortho-anisidine was tested for carcinogenicity in one experiment in mice and in one experiment in rats by dietary administration. It produced skin carcinomas in male rats, carcinomas of the Zymbal gland or skin of the ear in male and female rats, mammary adenocarcinomas in female rats and adenomas or carcinomas of the preputial and clitoral glands in male and female rats, respectively. The experiment in mice was inadequate for evaluation.

5-Nitro-ortho-anisidine was mutagenic to Salmonella typhimurium.

5.2 Human data

5-Nitro-ortho-anisidine has been produced commercially since at least 1937. Its principal use as a dye intermediate could result in occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of 5-nitro-ortho-anisidine in experimental animals.

No evaluation of the carcinogenicity of 5-nitro-ortho-anisidine to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)


Last updated: 8 April 1998

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