VOL.: 27 (1982) (p. 39)
Aniline was inactive in bacterial and mammalian DNA repair assays, in tests for mitotic recombination with yeast and in cell transformation assays. It did not induce chromosomal aberrations in mammalian cells or in animals. It was not mutagenic for the silkworm; nor was it mutagenic to Salmonella typhimurium unless both norharman and hepatic microsomes were present. Urines from treated rats were mutagenic for S. typhimurium with metabolic activation. Aniline induced sister chromatid exchanges in cultured mammalian cells.
The high risk of bladder cancer observed originally in workers in the aniline dye industry was probably due to exposure to chemicals other than aniline. Studies of individuals exposed to aniline but to no other known bladder carcinogens have shown little evidence of increased risk. The best of these reported one death from bladder cancer in 1223 men producing or using aniline, with 0.83 deaths expected from population rates. The degree of confidence which can be placed in the negative results obtained in the other studies is difficult to assess because of the absence of estimates of expected numbers of bladder cancers and the presumed lack of follow-up of workers who had left the industry.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 4 (1974)
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations