VOL.: 27 (1982) (p. 237)
Only studies on water fluoridation and cancer were reviewed. The relationship between cancer mortality or incidence and both natural and artificial fluoride in drinking-water has been investigated in a large number of descriptive epidemiological studies of population aggregates, carried out in Australia, Canada, New Zealand, Norway, the United Kingdom and the United States. Because of the uneven distribution of natural fluoride in the earth's crust, and the fact that local communities make independent decisions with regard to fluoridation, some of these studies could be viewed roughly as natural experiments. When proper account was taken of the differences among population units, in demographic composition, and in some cases also in their degree of industrialization and other social factors, none of the studies provided any evidence that an increased level of fluoride in water was associated with an increase in cancer mortality.
Variations geographically and in time in the fluoride content of water supplies provide no evidence of an association between fluoride ingestion and mortality from cancer in humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations