International Agency for Research on Cancer (IARC) - Summaries & Evaluations
4-CHLORO-ortho-PHENYLENEDIAMINE AND 4-CHLORO-meta-PHENYLENEDIAMINE
VOL.: 27 (1982) (p. 81)
CAS No.: 95-83-0
Chem. Abstr. Name: 1,2-Benzenediamine, 4-chloro-
CAS No.: 5131-60-2
Chem. Abstr. Name: 1,3-Benzenediamine, 4-chloro-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Both 4-chloro-ortho-phenylenediamine and
4-chloro-meta-phenylenediamine were tested for carcinogenicity in mice
and rats by dietary administration. 4-Chloro-ortho-phenylenediamine
was carcinogenic in mice, producing hepatocellular carcinomas in
animals of both sexes, and in rats of both sexes, producing benign and
malignant tumours of the urinary bladder. The results of the studies
with 4-chloro-meta-phenylenediamine in mice were inconclusive; those
in rats were not indicative of a carcinogenic effect.
4-Chloro-ortho-phenylenediamine was mutagenic to Salmonella
typhimurium after metabolic activation. No data were available on the
mutagenicity of 4-chloro-meta-phenylenediamine.
5.2 Human data
4-Chloro-ortho- and 4-chloro-meta-phenylenediamine have been produced
commercially since the early 1940s. The extent of present human
exposure is unknown. Both have been patented for use as hair-dye
No case report or epidemiological study was available to the Working
Group, but see Appendix 1, in this volume.
There is sufficient evidence for the carcinogenicity of
4-chloro ortho-phenylenediamine in experimental animals. In the
absence of data on humans, 4-chloro-ortho-phenylenediamine should be
regarded, for practical purposes, as if it presented a carcinogenic
risk to humans.
The available data were inadequate to evaluate the carcinogenicity of
4-chloro-meta-phenylenediamine in experimental animals. No evaluation
of the carcinogenicity of 4-chloro-meta-phenylenediamine to humans
could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 60: 4-chloro-ortho-phenylenediamine -
Group 2B; 4-chloro-meta-phenylenediamine - Group 3)
Synonyms for 4-Chloro-ortho-phenylenediamine
- C.I. 76015
- Ursol Olive 6G
Synonyms for 4-Chloro-meta-phenylenediamine
- C.I. 76027
Last updated: 8 April 1998