International Agency for Research on Cancer (IARC) - Summaries & Evaluations
4,4'-METHYLENEBIS(N,N-DIMETHYL)BENZENAMINE
VOL.: 27 (1982) (p. 119)
CAS No.: 101-61-1
Chem. Abstr. Name: Benzenamine, 4,4'-methylenebis(N,N-dimethyl)-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
4,4'-Methylenebis(N,N-dimethyl)benzenamine was tested in one
experiment in mice and in one experiment in rats by dietary
administration. It produced liver-cell adenomas in female mice and
thyroid follicular-cell carcinomas in male and female rats given the
highest dose.
4,4'-Methylenebis(N,N-dimethyl)benzenamine was positive in Escherichia
coli repair tests. It was mutagenic to Salmonella typhimurium, both
in vitro and in the murine host-mediated assay. It did not induce
mitotic recombination in yeast, but caused morphological
transformation in hamster embryo cells.
5.2 Human data
4,4'-Methylenebis(N,N-dimethyl)benzenamine has been
produced commercially since at least 1921. Its use as a dye
intermediate could result in occupational exposure.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is limited evidence for the carcinogenicity of
4,4'-methylenebis(N,N-dimethyl)benzenamine in experimental animals.
No evaluation of the carcinogenicity of
4,4'-methylenebis(N,N-dimethyl)benzenamine to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 3)
Synonyms
- 4,4'-Bis(dimethylamino)diphenylmethane
- para,para'-Bis(dimethylamino)diphenylmethane
- Bis[4-(dimethylamino)phenyl]methane
- Bis[4-(N,N-dimethylamino)phenyl)]methane
- Bis[para-(dimethylamino)phenyl]methane
- Bis[para-N,N-(dimethylamino)phenyl]methane
- Methane base
- Michler's Base
- Michler's hydride
- Michler's methane
- Tetrabase
- Tetramethyldiaminodiphenylmethane
- 4,4'-Tetramethyldiaminodiphenylmethane
- para,para'-Tetramethyldiaminodiphenylmethane
- N,N,N',N'-Tetramethyl-4,4'-diaminodiphenylmethane
- N,N,N',N'-Tetramethyl-para,para'-diaminodiphenylmethane
Last updated: 8 April 1998