International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 27 (1982) (p. 119)

CAS No.: 101-61-1
Chem. Abstr. Name: Benzenamine, 4,4'-methylenebis(N,N-dimethyl)-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

4,4'-Methylenebis(N,N-dimethyl)benzenamine was tested in one experiment in mice and in one experiment in rats by dietary administration. It produced liver-cell adenomas in female mice and thyroid follicular-cell carcinomas in male and female rats given the highest dose.

4,4'-Methylenebis(N,N-dimethyl)benzenamine was positive in Escherichia coli repair tests. It was mutagenic to Salmonella typhimurium, both in vitro and in the murine host-mediated assay. It did not induce mitotic recombination in yeast, but caused morphological transformation in hamster embryo cells.

5.2 Human data

4,4'-Methylenebis(N,N-dimethyl)benzenamine has been produced commercially since at least 1921. Its use as a dye intermediate could result in occupational exposure.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence for the carcinogenicity of 4,4'-methylenebis(N,N-dimethyl)benzenamine in experimental animals.

No evaluation of the carcinogenicity of 4,4'-methylenebis(N,N-dimethyl)benzenamine to humans could be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 66: Group 3)


Last updated: 8 April 1998

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