International Agency for Research on Cancer (IARC) - Summaries & Evaluations
N-NITROSODIPHENYLAMINE
VOL.: 27 (1982) (p. 213)
CAS No.: 86-30-6
Chem. Abstr. Name: Benzenamine, N-nitroso-N-phenyl-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
N-Nitrosodiphenylamine was adequately tested in one experiment in mice
and in one experiment in rats by dietary administration. No
carcinogenic effects were observed in mice. It was carcinogenic for
male and female rats, producing transitional-cell carcinomas of the
urinary bladder in animals given the high dose. In other experiments
the results were not indicative of carcinogenic effects, but there
were various inadequacies in the conducting and/or reporting of these
experiments.
N-Nitrosodiphenylamine has been extensively tested in short-term
assays in prokaryotes and eukaryotes for mutagenicity and other
chromosomal effects. It was not mutagenic and did not induce
unscheduled DNA synthesis or chromosomal damage under any test
condition employed.
5.2 Human data
N-Nitrosodiphenylamine has been produced commercially since at least
1945. Its use as a chemical intermediate and as a rubber processing
chemical could result in occupational exposure.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is limited evidence for the carcinogenicity of
N-nitrosodiphenylamine in experimental animals.
No evaluation of the carcinogenicity of N-nitrosodiphenylamine to
humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 3)
Synonyms
- Curetard A
- Delac J
- Diphenylnitrosamine
- Diphenyl N-nitrosoamine
- N,N-Diphenylnitrosamine
- Naugard TJB
- NDPA
- NDPhA
- Nitrosodiphenylamine
- N-Nitroso-N-phenylaniline
- Nitrous diphenylamide
- Redax
- Retarder J
- TJB
- Vulcalent A
- Vulcatard A
- Vulkalent A
- Vultrol
Last updated: 8 April 1998