International Agency for Research on Cancer (IARC) - Summaries & Evaluations
2,4,5- AND 2,4,6-TRIMETHYLANILINE
AND THEIR HYDROCHLORIDES
VOL.: 27 (1982) (p. 177)
2,4,5-Trimethylaniline
CAS No.: 137-17-7
Chem. Abstr. Name: Benzenamine, 2,4,5-trimethyl-
2,4,5-Trimethylaniline hydrochloride
CAS No.: 21436-97-5
Chem. Abstr. Name: Benzenamine, 2,4,5-trimethyl-, hydrochloride
2,4,6-Trimethylaniline
CAS No.: 88-05-1
Chem. Abstr. Name: Benzenamine, 2,4,6-trimethyl-
2,4,6-Trimethylaniline hydrochloride
CAS No.: 6334-11-8
Chem. Abstr. Name: Benzenamine, 2,4,6-trimethyl-, hydrochloride
5. Summary of Data Reported and Evaluation
5.1 Experimental data
2,4,5-Trimethylaniline and its hydrochloride were tested in two
experiments in mice and in two experiments in rats by dietary
administration. In one experiment in mice, 2,4,5-trimethylaniline
produced an increased incidence of hepatocellular carcinomas in female
mice. The other experiment in mice was considered inadequate for an
evaluation. In one experiment in rats it produced an increased
incidence of liver carcinomas and lung adenomas. In the other
experiment in rats no significantly increased incidence of tumours was
observed.
2,4,6-Trimethylaniline hydrochloride was tested in one experiment in
mice and in one experiment in male rats. These experiments were
considered inadequate for evaluation.
2,4,5-Trimethylaniline was mutagenic to Salmonella typhimurium with
metabolic activation. The available data were inadequate to evaluate
the mutagenicity of 2,4,6-trimethylaniline.
5.2 Human data
2,4,5-Trimethylaniline has been produced commercially in the past.
2,4,6-Trimethylaniline is believed to be produced in commercial
quantities, but its uses and the extent of human exposure are unknown.
The hydrochloride salts of these two compounds are not produced
commercially.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is limited evidence for the carcinogenicity of
2,4,5-trimethylaniline in experimental animals. No evaluation of the
carcinogenicity of 2,4,5-trimethylaniline to humans could be made.
The available data were inadequate for an evaluation of the
carcinogenicity of 2,4,6-trimethylaniline in experimental animals to
be made. No evaluation of the carcinogenicity of
2,4,6-trimethylaniline to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 3)
Synonyms for 2,4,5-Trimethylaniline
- 1-Amino-2,4,5-trimethylbenzene
- psi-Cumidine
- Pseudo-cumidine
- 1,2,4-Trimethyl-5-aminobenzene
Synonyms for 2,4,5-Trimethylaniline hydrochloride
- 1-Amino-2,4,5-trimethylbenzene hydrochloride
- psi-Cumidine hydrochloride
- Pseudocumidine hydrochloride
- 1,2,4-Trimethyl-5-aminobenzene hydrochloride
Synonyms for 2,4,6-Trimethylaniline
- Aminomesitylene
- 2-Aminomesitylene
- 2-Amino-1,3,5-trimethylbenzene
- Mesidin
- Mesidine
- Mesitylamine
Synonyms for 2,4,6-Trimethylaniline hydrochloride
- Aminomesitylene hydrochloride
- 2-Aminomesitylene hydrochloride
- 2-Amino-1,3,5-trimethylbenzene hydrochloride
- Mesidin hydrochloride
- Mesidine hydrochloride
- Mesitylamine hydrochloride
Last updated: 8 April 1998