VOL.: 29 (1982) (p. 73)
Benzotrichloride was mutagenic to bacteria with metabolic activation, and was positive in a rec-assay with Bacillus subtilis.
No data were available to assess the teratogenicity of this compound to experimental animals.
No data were available to assess the mutagenicity or teratogenicity of this compound to man.
No case report or epidemiological study involving exposure to benzotrichloride alone was available to the Working Group. Six cases of respiratory cancer have been reported among benzoyl chloride production workers in two small plants, who were also potentially exposed to benzotrichloride. The cases occurred in young workers, three of whom were nonsmokers.
Although the epidemiological data were inadequate to evaluate the carcinogenicity of benzotrichloride alone, they provide limited evidence that employment in the production of benzoyl chloride and its chlorinated toluene precursors, which involves exposure to benzotrichloride, represents a carcinogenic risk to man.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
See Also: Toxicological Abbreviations Benzotrichloride (ICSC)