VOL.: 29 (1982) (p. 49)
Benzyl chloride is a direct-acting mutagen to bacteria. It induces mitotic recombination in yeast and transforms hamster embryo cells.
The available data are inadequate to assess the teratogenicity of this compound to experimental animals.
No data were available to assess the mutagenicity or teratogenicity of this compound to man.
No case report or epidemiological study involving exposure to benzyl chloride alone was available to the Working Group. Six cases of respiratory cancer have been reported among benzoyl chloride manufacturing workers in two small plants, who were also potentially exposed to benzyl chloride. The cases occurred in relatively young workers, three of whom were nonsmokers.
Although the epidemiological data were inadequate to evaluate the carcinogenicity of benzyl chloride alone, they provide limited evidence that employment in the production of benzoyl chloride and its chlorinated toluene precursors, which involves exposure to benzyl chloride, represents a carcinogenic risk to man.
No evaluation could be made of the carcinogenicity to man of benzyl chloride itself.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 11 (1976)
Subsequent evaluation: Vol. 71 (1999)
See Also: Toxicological Abbreviations Benzyl chloride (ICSC) Benzyl Chloride (IARC Summary & Evaluation, Volume 11, 1976)