International Agency for Research on Cancer (IARC) - Summaries & Evaluations
DI(2-ETHYLHEXYL) ADIPATE
VOL.: 29 (1982) (p. 257)
CAS No.: 103-23-1
Chem. Abstr. Name: Hexanedioic acid, bis(2-ethylhexyl) ester
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Di(2-ethylhexyl) adipate was tested in mice and rats by oral
administration. It induced significant increases in the incidence of
liver-cell tumours in male and female mice. No increase in tumour
incidence was observed in rats.
The data were inadequate to assess the teratogenicity of this
compound to experimental animals.
Di(2-ethylhexyl) adipate induces dominant lethal mutations and reduces
fertility in mice. Mutagenicity tests in Salmonella typhimurium were
negative.
5.2 Human data
Occupational exposure to di(2-ethylhexyl) adipate occurs during its
production, its use as a plasticizer and its use as a lubricant and
functional fluid. Its presence as a plasticizer in polyvinyl chloride
film used for wrapping food may result in exposure of the general
public.
No data were available to assess the mutagenicity or teratogenicity
of this compound to man.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is limited evidence that di(2-ethylhexyl) adipate is
carcinogenic in mice.
No case report or epidemiological study on this compound was
available.
No evaluation could be made of the carcinogenicity of 2-ethylhexyl)
adipate to man.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 77 (2000)
Synonyms
- Adipol 2EH
- BEHA
- Bis(2-ethylhexyl) adipate
- Bisoflex DOA
- DEHA
- Di-2-ethyl hexyl adipate
- Dioctyl adipate
- DOA
- Effomoll DOA
- Ergoplast AdDO
- Flexol A26
- Hexanedioic acid, dioctyl ester
- Kodaflex DOA
- Mollan S
- Monoplex DOA
- Octyl adipate
- Plastomoll DDA
- PX-238
- Reomol DOA
- Rucoflex Plasticizer DOA
- Sicol 250
- Staflex DOA
- Truflex DOA
- Uniflex DOA
- Vestinol OA
- Wickenol 158
- Witamol 320
Last updated: 9 April 1998