International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 29 (1982) (p. 257)

CAS No.: 103-23-1
Chem. Abstr. Name: Hexanedioic acid, bis(2-ethylhexyl) ester

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Di(2-ethylhexyl) adipate was tested in mice and rats by oral administration. It induced significant increases in the incidence of liver-cell tumours in male and female mice. No increase in tumour incidence was observed in rats.

The data were inadequate to assess the teratogenicity of this compound to experimental animals.

Di(2-ethylhexyl) adipate induces dominant lethal mutations and reduces fertility in mice. Mutagenicity tests in Salmonella typhimurium were negative.

5.2 Human data

Occupational exposure to di(2-ethylhexyl) adipate occurs during its production, its use as a plasticizer and its use as a lubricant and functional fluid. Its presence as a plasticizer in polyvinyl chloride film used for wrapping food may result in exposure of the general public.

No data were available to assess the mutagenicity or teratogenicity of this compound to man.

No case report or epidemiological study was available to the Working Group.

5.3 Evaluation

There is limited evidence that di(2-ethylhexyl) adipate is carcinogenic in mice.

No case report or epidemiological study on this compound was available.

No evaluation could be made of the carcinogenicity of 2-ethylhexyl) adipate to man.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 77 (2000)


Last updated: 9 April 1998

    See Also:
       Toxicological Abbreviations
       Di(2-ethylhexyl) adipate  (IARC Summary & Evaluation, Volume 77, 2000)