International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 29 (1982) (p. 269)

CAS No.: 117-81-7
Chem. Abstr. Name: 1,2-Benzenedicarboxylic acid, bis(2-ethylhexyl)

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Di(2-ethylhexyl) phthalate was tested in mice and rats by oral administration: It significantly increased the incidence of benign and malignant liver-cell tumours in animals of both species, and a dose-response relationship was observed.

Di(2-ethylhexyl) phthalate can cause testicular damage in rats. There is evidence that this compound and its metabolite, mono(2-ethylhexyl) phthalate, are teratogenic and embryolethal to rodents.

Di(2-ethylhexyl) phthalate was not mutagenic to Salmonella typhimurium. However, it caused dominant lethal mutations in mice after systemic but not oral administration.

5.2 Human data

Occupational exposure to di(2-ethylhexyl) phthalate probably occurs during its manufacture, its use as a plasticizer, its use in dielectric fluids for electrical capacitors and in the further processing or use of plasticized products containing it. Its reported widespread occurrence in ambient air, in drinking, river and ocean waters, in industrial effluents, in foods and in blood stored in plasticized bags indicates environmental exposure and exposure of the general human population.

No data were available to assess the mutagenicity or teratogenicity of this compound to man.

No adequate epidemiological study was available to the Working Group.

5.3 Evaluation

There is sufficient evidence for the carcinogenicity of di(2-ethylhexyl) phthalate in mice and rats.

No adequate epidemiological study was available.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Vol. 77 (2000)


Last updated: 9 April 1998

    See Also:
       Toxicological Abbreviations
       Di(2-ethylhexyl) phthalate (ICSC)
       Di(2-ethylhexyl) phthalate  (IARC Summary & Evaluation, Volume 77, 2000)