International Agency for Research on Cancer (IARC) - Summaries & Evaluations
para-BENZOQUINONE DIOXIME
VOL.: 29 (1982) (p. 185)
CAS No.: 105-11-3
Chem. Abstr. Name: 2,5-Cyclohexadiene-1,4-dione, dioxime
5. Summary of Data Reported and Evaluation
5.1 Experimental data
para-Benzoquinone dioxime was tested for carcinogenicity at two dose
levels in mice and rats by oral administration. No significant
increase in the number of neoplasms was observed in male rats; but in
females given the high dose, a significant increase in the number of
transitional-cell papillomas and carcinomas of the urinary bladder
occurred. In mice, no carcinogenic effect was observed.
No data were available to assess the mutagenicity or teratogenicity of
this compound.
5.2 Human data
Occupational exposure to para-benzoquinone dioxime probably occurs
during its manufacture, its use as a rubber vulcanizing agent and its
conversion to chemical derivatives.
No data were available to assess the mutagenicity or teratogenicity of
this compound to man.
No case report or epidemiological study was available to the Working
Group.
5.3 Evaluation
There is limited evidence that para-benzoquinone dioxime is
carcinogenic to rats.
No case report or epidemiological study was available.
No evaluation could be made of the carcinogenicity of
para-benzoquinone dioxime to man.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
Synonyms para-Benzoquinone Dioxime
- Actor Q
- 1,4-Benzoquinone dioxine
- Dibenzo PQD
- G-M-F
- PQD
- QDO
- para-Quinone dioxime
- para-Quinone oxime
Last updated: 9 April 1998