VOL.: 30 (1983) (p. 347)
No data were available to evaluate the teratogenicity of 1-naphthylthiourea to experimental animals.
1-Naphthylthiourea was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic activation system. It induced a transformed phenotype in Syrian hamster embryo cells in vitro. There is limited evidence that 1-naphthylthiourea is mutagenic in cellular systems. No data were available to evaluate its mutagenicity to mammals.
No data were available to evaluate the teratogenic or chromosomal effects of 1-naphthylthiourea in humans.
No case report or epidemiological study of the carcinogenicity of 1-naphthylthiourea was available to the Working Group.
The available data are insufficient to evaluate the carcinogenicity of 1-naphthylthiourea to humans.
N.B. - Subsequent to the meeting, the Working Group became aware of a study by Davies et al. (1982) in which 12 cases of urothelial tumour were reported among rodent operatives in England who used 1-naphthylthiourea which contained up to 0.2% 2-naphthylamine.
Subsequent evaluation: Suppl. 7 (1987)
See Also: Toxicological Abbreviations