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International Agency for Research on Cancer (IARC) - Summaries & Evaluations

DIALLATE

VOL.: 30 (1983) (p. 235)

CAS No.: 2303-16-4
Chem. Abstr. Name: Carbamothioic acid, bis(1-methylethyl)-, S-(2,3-dichloro-2-
propenyl)ester

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Diallate was tested for carcinogenicity in two strains of mice by oral and subcutaneous administration and in one strain of rats by oral administration. Following its administration in the diet, the incidence of hepatomas was increased in male mice of both strains, and the incidence of lung adenomas was increased in male mice of one strain. The study in rats was considered to be inadequate for evaluation.

No data were available to evaluate the teratogenicity of diallate to experimental animals.

Diallate was mutagenic in bacteria and yeasts. It induced mutations in Drosophila melanogaster, and unscheduled DNA synthesis, sister chromatid exchange, gene mutations and chromosomal aberrations in cultured mammalian cells. Exogenous metabolic activation was usually required to produce or enhance mutagenic activity. Diallate was ineffective in a dominant lethal test in mice. There is sufficient evidence that diallate is mutagenic in cellular systems, but insufficient evidence for its mutagenicity in mammals.

5.2 Human data

Diallate was introduced in 1960. Its production, formulation and use as a herbicide in agricultural applications are potential sources of exposure, both of workers and of the general population.

No data were available to evaluate the teratogenic or chromosomal effects of diallate in humans.

No case report or epidemiological study of the carcinogenicity of diallate alone was available to the Working Group. (See, however, the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)

5.3 Evaluation

Results of experiments in mice provide limited evidence that diallate is carcinogenic to experimental animals. No data on humans were available.

The available data are insufficient to evaluate the carcinogenicity of diallate to humans.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 12 (1976)

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)

Synonyms

Last updated: 16 April 1998 






























    See Also:
       Toxicological Abbreviations
       Diallate (IARC Summary & Evaluation, Volume 12, 1976)