VOL.: 30 (1983) (p. 235)
Chem. Abstr. Name: Carbamothioic acid, bis(1-methylethyl)-, S-(2,3-dichloro-2-
No data were available to evaluate the teratogenicity of diallate to experimental animals.
Diallate was mutagenic in bacteria and yeasts. It induced mutations in Drosophila melanogaster, and unscheduled DNA synthesis, sister chromatid exchange, gene mutations and chromosomal aberrations in cultured mammalian cells. Exogenous metabolic activation was usually required to produce or enhance mutagenic activity. Diallate was ineffective in a dominant lethal test in mice. There is sufficient evidence that diallate is mutagenic in cellular systems, but insufficient evidence for its mutagenicity in mammals.
No data were available to evaluate the teratogenic or chromosomal effects of diallate in humans.
No case report or epidemiological study of the carcinogenicity of diallate alone was available to the Working Group. (See, however, the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)
The available data are insufficient to evaluate the carcinogenicity of diallate to humans.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 12 (1976)
Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)
See Also: Toxicological Abbreviations Diallate (IARC Summary & Evaluation, Volume 12, 1976)