International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 30 (1983) (p. 245)

CAS No.: 2164-17-2
Chem. Abstr. Name: Urea, N,N-dimethyl-N'-[3-(trifluoromethyl)phenyl]-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Fluometuron was tested for carcinogenicity in mice and rats by administration in the diet. In male mice, an increased incidence of liver-cell tumours was found. In female mice and in rats of both sexes, the results were not indicative of a carcinogenic effect.

No data were available to evaluate the teratogenicity of fluometuron to experimental animals.

Fluometuron was weakly or nonmutagenic to Salmonella typhimurium. It was not active in inducing mitotic gene conversion in yeast. Mitotic chromosomal aberrations were observed in treated Vicia faba root tips and cotton seeds. In all studies that gave positive results, commercial formulations were known or suspected to have been used, suggesting that the observed activity may be attributable to other ingredients. There are insufficient data to evaluate the mutagenicity of pure fluometuron, but there is limited evidence that commercial formulations of this compound are mutagenic in experimental animals.

5.2 Human data

Fluometuron was introduced in 1960. Its production, formulation and use as a herbicide on cotton are potential sources of exposure, both of workers and of the general population.

No data were available to evaluate the teratogenicity of fluometuron to humans. The available data were insufficient to evaluate its chromosomal effects in humans.

No case report or epidemiological study of the carcinogenicity of fluometuron alone was available to the Working Group. (See also the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)

5.3 Evaluation

The available data are inadequate to evaluate the carcinogenicity of fluometuron to experimental animals. No data on humans were available.

No evaluation of the carcinogenicity of fluometuron to humans can be made.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 63: Group 3)


Last updated: 16 April 1998

    See Also:
       Toxicological Abbreviations