VOL.: 30 (1983) (p. 271)
Chem. Abstr. Name: Benzene, 2,4-dichloro-1-(4-nitrophenoxy)-
Nitrofen was teratogenic to mice and rats when given at very high doses. It decreased neonatal and postnatal viability in three-generation reproduction studies in rats.
Nitrofen was mutagenic to Salmonella typhimurium. In two studies, there was no evidence for chromosomal damage in mammals. The data are insufficient to evaluate the mutagenicity of nitrofen in mammals.
No data were available to evaluate the teratogenic or chromosomal effects of nitrofen in humans.
No case report or epidemiological study of the carcinogenicity of nitrofen alone was available to the Working Group; however, it should be noted that the period since introduction of this compound may be too short for a carcinogenic effect to be detected in humans. (See also the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)
There is sufficient evidence that technical-grade nitrofen is carcinogenic to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 67: Group 2B)
See Also: Toxicological Abbreviations Nitrofen (ICSC) Nitrofen (Pesticide residues in food: 1983 evaluations)