International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 30 (1983) (p. 197)

CAS No.: 22248-79-9
Chem. Abstr. Name: Phosphoric acid, 2-chloro-1-(2,4,5-trichlorophenyl)ethenyl dimethyl ester, (Z)-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Tetrachlorvinphos was tested for carcinogenicity in mice and rats by administration in the diet. It produced hepatocellular carcinomas in male mice and benign and malignant liver-cell tumours in female mice. In rats, it increased the incidences of C-cell adenoma of the thyroid and of cortical adenoma of the adrenal in females.

No data were available to evaluate the teratogenicity of tetrachlorvinphos to experimental animals.

Tetrachlorvinphos was not mutagenic to bacteria in the systems studied. It was a weak inducer of chromosomal aberrations in human lymphocytes in vitro. No overall evaluation of the mutagenicity of tetrachlorvinphos could be made.

5.2 Human data

Tetrachlorvinphos was introduced in 1966. Its production, formulation and use as an insecticide on livestock and poultry are potential sources of exposure, both of workers and of the general population.

No data were available to evaluate the teratogenic or chromosomal effects of tetrachlorvinphos in humans.

No case report or epidemiological study of the carcinogenicity of tetrachlorvinphos alone was available to the Working Group; however, it should be noted that the period since introduction of this compound may be too short for a carcinogenic effect to be detected in humans. (See also the section 'Cancer Epidemiology of Pesticide Manufacturers, Formulators and Users', in this volume.)

5.3 Evaluation

Results of experiments in mice and rats provide limited evidence that tetrachlorvinphos is carcinogenic to experimental animals. No data on humans were available.

The available data are insufficient to evaluate the carcinogenicity of tetrachlorvinphos to humans. likely to present a carcinogenic risk to humans.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 3)


Last updated: 16 April 1998

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