International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 30 (1983) (p. 197)
CAS No.: 22248-79-9
Chem. Abstr. Name: Phosphoric acid,
2-chloro-1-(2,4,5-trichlorophenyl)ethenyl dimethyl ester, (Z)-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Tetrachlorvinphos was tested for carcinogenicity in mice and rats
by administration in the diet. It produced hepatocellular carcinomas
in male mice and benign and malignant liver-cell tumours in female
mice. In rats, it increased the incidences of C-cell adenoma of the
thyroid and of cortical adenoma of the adrenal in females.
No data were available to evaluate the teratogenicity of
tetrachlorvinphos to experimental animals.
Tetrachlorvinphos was not mutagenic to bacteria in the systems
studied. It was a weak inducer of chromosomal aberrations in human
lymphocytes in vitro. No overall evaluation of the mutagenicity of
tetrachlorvinphos could be made.
5.2 Human data
Tetrachlorvinphos was introduced in 1966. Its production,
formulation and use as an insecticide on livestock and poultry are
potential sources of exposure, both of workers and of the general
No data were available to evaluate the teratogenic or chromosomal
effects of tetrachlorvinphos in humans.
No case report or epidemiological study of the carcinogenicity of
tetrachlorvinphos alone was available to the Working Group; however,
it should be noted that the period since introduction of this compound
may be too short for a carcinogenic effect to be detected in humans.
(See also the section 'Cancer Epidemiology of Pesticide Manufacturers,
Formulators and Users', in this volume.)
Results of experiments in mice and rats provide limited evidence that tetrachlorvinphos
is carcinogenic to experimental animals. No
data on humans were available.
The available data are insufficient to evaluate the
carcinogenicity of tetrachlorvinphos to humans.
likely to present a carcinogenic risk to humans.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 72: Group 3)
- 2-Chloro-1-(2,4,5-trichlorophenyl)vinyl dimethyl phosphate
- 2-Chloro-1-(2,4,5-trichlorophenyl)vinyl phosphoric acid dimethyl ester
- Dimethyl 2,4,5-trichloro-a-(chloromethylene)benzyl phosphate
- Dimethyl-1-(2,4,5-trichlorophenyl)-2-chlorovinyl phosphate
- Dust M
- ENT 2541
- NCI CO0168
- Rabon Oral Larvicide (ROL)
- Rabond Ravap
- SD 8447
- 2,4,5-Trichloro-a-(chloromethylene)benzyl alcohol, dimethyl phosphate
Last updated: 16 April 1998