International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 31 (1983) (p. 71)
CAS No.: 121-66-4
Chem. Abstr. Name: 2-Thiazolamine, 5-nitro-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
2-Amino-5-nitrothiazole was tested for carcinogenicity in one
experiment in mice and in two experiments in two strains of rats by
administration in the diet. In one experiment in female rats,
2-amino-5-nitrothiazole increased the incidence of benign mammary
tumours. In the other experiment in rats it increased the incidences
of malignant lymphomas, lymphocytic and undifferentiated leukaemias,
and granulocytic leukaemias in male rats. The results of studies in
mice were not indicative of a carcinogenic effect.
2-Amino-4-nitrothiazole was mutagenic in bacteria. The data were
inadequate to evaluate the activity of this compound in short-term
No data were available to evaluate the teratogenicity of this
compound to experimental animals.
5.2 Human data
2-Amino-5-nitrothiazole, a synthetic veterinary antiprotozoal
agent, has been produced and used since 1950. It is also used as an
intermediate in the manufacture of disperse azo dyes. Manufacturers
of the compound itself, handlers of feed and people involved in the
synthesis of the dyes concerned are exposed to
No data were available to assess the teratogenicity or
chromosomal effects of this compound in humans.
No case report or epidemiological study of the carcinogenicity of
2-amino-5-nitrothiazole was available to the Working Group.
There is limited evidence for the carcinogenicity of
2-amino-5-nitrothiazole in experimental animals. In the absence of
epidemiological data, no evaluation of the carcinogenicity of
2-amino-5-nitrothiazole to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 57: Group 3)
- Amnizol soluble
- Enheptin Premix
- Enheptin T
- NCI CO3065
- Nitramin Ido
Last updated: 16 April 1998