International Agency for Research on Cancer (IARC) - Summaries & Evaluations
CINNAMYL ANTHRANILATE
VOL.: 31 (1983) (p. 133)
CAS No.: 87-29-6
Chem. Abstr. Name: Benzoic acid, 2-amino-, 3-phenyl-2-propenyl ester
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Cinnamyl anthranilate was tested for carcinogenicity in mice and
rats by administration in the diet and in mice by intraperitoneal
injection. In mice, a dose-related increase in the incidence of
hepatocellular tumours was found following its oral administration and
an increased incidence of lung tumours following its intraperitoneal
injection. The study in rats could not be evaluated.
Cinnamyl anthranilate was not mutagenic to Salmonella
typhimurium. The data were inadequate to evaluate the activity of
this compound in short-term tests.
No data were available to evaluate the teratogenicity of this
compound to experimental animals.
5.2 Human data
Cinnamyl anthranilate has been used since at least 1939, but its
use during the last few years has diminished. Its consumption as a
flavouring agent and to a lesser extent as a fragrance in cosmetics
are sources of exposure for the general population.
No data were available to evaluate the teratogenicity or
chromosomal effects of this compound in humans.
No case report or epidemiological study of the carcinogenicity of
cinnamyl anthranilate was available to the Working Group.
5.3 Evaluation
There is limited evidence for the carcinogenicity of cinnamyl
anthranilate in experimental animals. In the absence of
epidemiological data, no evaluation of the carcinogenicity of cinnamyl
anthranilate to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 16 (1978)
Subsequent evaluation: Suppl. 7 (1987) (p. 60: Group 3); Vol. 77 (2000)
Synonyms
- Anthranilic acid, cinnnamyl ester
- Cinnamyl alcohol anthranilate
- Cinnamyl 2-aminobenzoate
- Cinnamyl ortho-aminobenzoate
- 3-Phenyl-2-propen-1-yl anthranilate
- 3-Phenyl-2-propenyl anthranilate
Last updated: 16 April 1998
See Also:
Toxicological Abbreviations
Cinnamyl anthranilate (WHO Food Additives Series 16)
CINNAMYL ANTHRANILATE (JECFA Evaluation)
Cinnamyl Anthranilate (IARC Summary & Evaluation, Volume 16, 1978)
Cinnamyl anthranilate (IARC Summary & Evaluation, Volume 77, 2000)