International Agency for Research on Cancer (IARC) - Summaries & Evaluations
KAEMPFEROL
VOL.: 31 (1983) (p. 171)
CAS No.: 520-18-3
Chem. Abstr. Name: 4H-1-Benzopyran-4-one,
3,5,7-trihydroxy-2-(4-hydroxyphenyl)-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Kaempferol was tested for carcinogenicity in one experiment in
rats by administration in the diet. The data are inadequate to make
an evaluation.
Kaempferol was mutagenic in bacteria and insects and in mammalian
cells in vitro; it induced micronuclei in mice. There is limited
evidence that kaempferol is active in short-term tests.
No data were available to evaluate the teratogenicity of
kaempferol to experimental animals.
5.2 Human data
The natural occurrence of kaempferol, an aglycone widely
distributed in fruit and other edible plants, results in wide human
exposure to this compound.
No data were available to evaluate the teratogenicity or
chromosomal effects of this compound in humans.
No case report or epidemiological study of the carcinogenicity of
kaempferol was available to the Working Group.
5.3 Evaluation
The available data were inadequate to evaluate the
carcinogenicity of kaempferol to experimental animals. In the absence
of epidemiological data, no evaluation of the carcinogenicity of
kaempferol to humans could be made.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 65: Group 3)
Synonyms
- Campherol
- C.I. 75640
- Indigo yellow
- Kaempherol
- Kampherol
- Kempferol
- Nimbecetin
- Pelargidenolon 1497
- Populnetin
- Rhamnolutein
- Rhamnolutin
- Robigenin
- Swartziol
- Trifolitin
- 5,7,4'-Trihydroxyflavonol
Last updated: 16 April 1998