International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 31 (1983) (p. 185)

CAS No.: 804-36-4
Chem. Abstr. Name: Hydrazinecarboximidamide, 2-[3-(5-nitro-2-furanyl)-1-[2-(5-nitro-2-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Nitrovin was tested for carcinogenicity in one experiment in female rats by administration in the diet. The experiment was inadequate for evaluation.

Nitrovin induces DNA damage and mutations in bacteria and mutations in insects. There is limited evidence that nitrovin is active in short-term tests.

No data were available to evaluate the teratogenicity of this compound to experimental animals.

5.2 Human data

Nitrovin, a veterinary bacteriostatic and bactericidal compound, has been used since 1952 as a growth promotor in chickens. Humans may be exposed as a result of its manufacture and use in veterinary medicine.

No data were available to assess the teratogenicity or chromosomal effects of this compound in humans.

No case report or epidemiological study of the carcinogenicity of nitrovin was available to the Working Group.

5.3 Evaluation

No evaluation of the carcinogenicity of nitrovin to experimental animals could be made. In the absence of epidemiological data, no evaluation of the carcinogenicity of nitrovin to humans could be made.

Subsequent evaluation: Suppl. 7 (1987) (p. 68: Group 3)


Last updated: 16 April 1998

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