International Agency for Research on Cancer (IARC) - Summaries & Evaluations
TRP-P-1 (3-AMINO-1,4-DIMETHYL-5H-PYRIDO[4,3-b]INDOLE)
AND ITS ACETATE
VOL.: 31 (1983) (p. 247)
Trp-P-1
CAS No.: 62450-06-0
Chem. Abstr. Name: 5H-Pyrido[4,3-b]indol-3-amine, 1,4-dimethyl-
Trp-P-1 acetate
CAS No.: 75104-43-7 (acetate); 68808-54-8 (monoacetate)
Chem. Abstr. Name: 5H-Pyrido[4,3-b]indol-3-amine, 1,4-dimethyl-,
acetate; 5H-pyrido[4,3-b]indol-3-amine, 1,4-dimethyl-, monoacetate
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Trp-P-1 was tested for carcinogenicity in mice by administration
in the diet, by skin application and by bladder implantation, and in
rats and hamsters by subcutaneous administration. Hepatic tumours
were induced by oral administration in both male and female mice,
although the increased incidence was significant only in females. In
female rats, there was a significant increase in the incidence of
fibrosarcomas at the site of injection; in hamsters there was an
increased incidence of subcutaneous sarcomas. Bladder carcinomas were
observed in female mice after implantation of paraffin pellets
containing Trp-P-1 at this site. The study in mice by skin painting
was inadequate for evaluation.
Trp-P-1 is mutagenic to bacteria following metabolic activation.
It induced chromosomal anomalies in mammalian cells, including human
cells, in vitro. It also caused morphological transformation of
hamster embryo cells. There is sufficient evidence that Trp-P-1 is
active in short-term tests.
No data were available to evaluate the teratogenicity of this
compound to experimental animals.
5.2 Human data
Trp-P-1 is found in the charred fraction of cooked fish and meat,
and the consumption of these foods is a source of exposure for the
general population.
No data were available to evaluate the teratogenicity or
chromosomal effects of this compound in humans.
No case report or epidemiological study of the carcinogenicity of
Trp-P-1 was available to the Working Group.
5.3 Evaluation
There is sufficient evidence for the carcinogenicity of Trp-P-1
in experimental animals. No data on humans were available.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 73: Group 2B)
Synonyms for Tr-P-1
- 3-Amino-1,4-dimethyl-g-carboline
- TRP-Pl
- Tryptophan P1
Synonyms for Tr-P-1 acetate
- 3-Amino-1,4-dimethyl-5H-pyrido[4,3-b]indole acetate
Last updated: 16 April 1998