International Agency for Research on Cancer (IARC) - Summaries & Evaluations
1,4-DIMETHYLPHENANTHRENE
VOL.: 32 (1983) (p. 349)
CAS No.: 22349-59-3
Chem. Abstr. Name: Phenanthrene, 1,4-dimethyl-
5. Summary of Data Reported and Evaluation
5.1 Experimental data
1,4-Dimethylphenanthrene was tested only for tumour-initiating
activity in the mouse-skin initiation-promotion assay. It was active
as an initiator.
No data on the teratogenicity of this compound were available.
1,4-Dimethylphenanthrene was mutagenic to Salmonella typhimurium
in the presence of an exogenous metabolic system and induced
unscheduled DNA synthesis in cultured primary rat hepatocytes.
There is limited evidence that 1,4-dimethylphenanthrene is active
in short-term tests.
5.2 Human data
Humans are exposed to dimethylphenanthrenes in tobacco smoke and
urban air; however, 1,4-dimethylphenanthrene has not been
specifically identified.
5.3 Evaluation
The available data were inadequate to permit an evaluation of the
carcinogenicity of 1,4-dimethylphenanthrene per se to experimental
animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 3)
Last updated: 17 April 1998