International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 349)

CAS No.: 22349-59-3
Chem. Abstr. Name: Phenanthrene, 1,4-dimethyl-

5. Summary of Data Reported and Evaluation

5.1 Experimental data

1,4-Dimethylphenanthrene was tested only for tumour-initiating activity in the mouse-skin initiation-promotion assay. It was active as an initiator.

No data on the teratogenicity of this compound were available.

1,4-Dimethylphenanthrene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system and induced unscheduled DNA synthesis in cultured primary rat hepatocytes.

There is limited evidence that 1,4-dimethylphenanthrene is active in short-term tests.

5.2 Human data

Humans are exposed to dimethylphenanthrenes in tobacco smoke and urban air; however, 1,4-dimethylphenanthrene has not been specifically identified.

5.3 Evaluation

The available data were inadequate to permit an evaluation of the carcinogenicity of 1,4-dimethylphenanthrene per se to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 62: Group 3)

Last updated: 17 April 1998

    See Also:
       Toxicological Abbreviations