International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 129)

CAS No.: 225-51-4
Chem. Abstr. Name: Benz(c)acridine

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benz[c]acridine was tested for carcinogenicity in one experiment in mice by skin application and produced a low incidence of skin tumours. It was also tested in the mouse-skin initiation-promotion assay and was inactive as an initiator. It was also tested in rats by bladder implantation in wax pellets; an increased incidence of bladder tumours was observed.

No data on the teratogenicity of this compound were available.

Benz[c]acridine was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system.

There is inadequate evidence that benz[c]acridine is active in short-term tests.

5.2 Human data

Benz[c]acridine is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to benz[c]acridine occurs primarily through the inhalation of polluted air and by ingestion of food and water contaminated with combustion products.

5.3 Evaluation

There is limited evidence that benz[c]acridine is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 3 (1973)

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)


Last updated: 17 April 1998

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       Toxicological Abbreviations