International Agency for Research on Cancer (IARC) - Summaries & Evaluations
BENZ[c]ACRIDINE
VOL.: 32 (1983) (p. 129)
CAS No.: 225-51-4
Chem. Abstr. Name: Benz(c)acridine
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Benz[c]acridine was tested for carcinogenicity in one experiment
in mice by skin application and produced a low incidence of skin
tumours. It was also tested in the mouse-skin initiation-promotion
assay and was inactive as an initiator. It was also tested in rats by
bladder implantation in wax pellets; an increased incidence of bladder
tumours was observed.
No data on the teratogenicity of this compound were available.
Benz[c]acridine was mutagenic to Salmonella typhimurium in the
presence of an exogenous metabolic system.
There is inadequate evidence that benz[c]acridine is active in
short-term tests.
5.2 Human data
Benz[c]acridine is present as a minor component of the total
content of polynuclear aromatic compounds in the environment. Human
exposure to benz[c]acridine occurs primarily through the inhalation of
polluted air and by ingestion of food and water contaminated with
combustion products.
5.3 Evaluation
There is limited evidence that benz[c]acridine is carcinogenic to
experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Previous evaluation: Vol. 3 (1973)
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)
Synonyms
- 12-Azabenz(a)anthracene
- B(c)AC
- 3,4-Benzacridine
- 3,4-Benzoacridine
- a-Chrysidine
- a-Naphthacridine
Last updated: 17 April 1998