International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 177)

CAS No.: 238-84-6
Chem. Abstr. Name: 11H-Benzo(a)fluorene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benzo[a]fluorene was tested for carcinogenicity in mice in one study by skin application and in a mouse-skin initiation-promotion assay. Negative results were obtained in both studies. In a study involving subcutaneous administration of benzo[a]fluorene to mice, no injection-site tumour was observed.

No data on the teratogenicity of this chemical were available.

The available data were inadequate to evaluate the mutagenicity of benzo[a]fluorene to Salmonella typhimurium.

There is inadequate evidence that benzo[a]fluorene is active in short-term tests.

5.2 Human data

Benzo[a]fluorene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to benzo[a]fluorene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated with combustion products.

5.3 Evaluation

The available data were inadequate to permit an evaluation of the carcinogenicity of benzo[a]fluorene to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)


Last updated: 17 April 1998

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