International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 147)

CAS No.: 205-99-2
Chem. Abstr. Name: Benz(e)acephenanthrylene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benzo[b]fluoranthene has been shown to be carcinogenic to experimental animals.

No data on the teratogenicity of this compound were available.

Benzo[b]fluoranthene was mutagenic to Salmonella typhimurium in the presence of an exogenous metabolic system. In the one available study it was reported to induce sister chromatid exchange but not chromosomal aberrations in bone-marrow cells of hamsters treated in vivo.

There is inadequate evidence that benzo[b]fluoranthene is active in short-term tests.

5.2 Human data

Benzo[b]fluoranthene is present as a major component of the total content of polynuclear aromatic compounds in the environment. Human exposure to benzo[b]fluoranthene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated by combustion effluents.

5.3 Evaluation

There is sufficient evidence that benzo[b]fluoranthene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Previous evaluation: Vol. 3 (1973)

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 2B)


Last updated: 17 April 1998

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       Toxicological Abbreviations