International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p.189)

CAS No.: 205-12-9
Chem. Abstr. Name: 7H-Benzo(c)fluorene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Benzo[c]fluorene was tested for carcinogenicity in mice in one experiment by skin application and in one mouse-skin initiation-promotion assay. There was no indication of carcinogenic or initiating activity.

No data on the teratogenicity of this compound were available.

The single report of mutagenicity of benzo[c]fluorene in Salmonella typhimurium was inconclusive.

There is inadequate evidence that benzo[c]fluorene is active in short-term tests.

5.2 Human data

Benzo[c]fluorene is present as a minor component of the total content of polynuclear aromatic compounds in the environment. Human exposure to benzo[c]fluorene occurs primarily through the smoking of tobacco, inhalation of polluted air and by ingestion of food and water contaminated with combustion products.

5.3 Evaluation

The available data were inadequate to permit an evaluation of the carcinogenicity of benzo[c]fluorene to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)


Last updated: 17 April 1998

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       Toxicological Abbreviations