International Agency for Research on Cancer (IARC) - Summaries & Evaluations
VOL.: 32 (1983) (p. 171)
CAS No.: 203-12-3
Chem. Abstr. Name: Benzo(ghi)fluoranthene
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Benzo[ghi]fluoranthene was tested for carcinogenicity in one
study in female mice by skin painting; no skin tumour was observed.
No data on the teratogenicity of this compound were available.
In the one available study, benzo[ghi]fluoranthene was mutagenic
to Salmonella typhimurium in the presence of an exogenous metabolic
There is inadequate evidence that benzo[ghi]fluoranthene is
active in short-term tests.
5.2 Human data
Benzo[ghi]fluoranthene is present as a component of the total
content of polynuclear aromatic compounds in the environment. Human
exposure to benzo[ghi]fluoranthene occurs primarily through the
smoking of tobacco, inhalation of polluted air and by ingestion of
food and water contaminated by combustion effluents.
The available data are inadequate to permit an evaluation of the
carcinogenicity of benzo[ghi]fluoranthene to experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Suppl. 7 (1987) (p. 58: Group 3)
Last updated: 17 April 1998