International Agency for Research on Cancer (IARC) - Summaries & Evaluations
CARBAZOLE
VOL.: 32 (1983) (p. 239)
CAS No.: 86-74-8
Chem. Abstr. Name: 9H-Carbazole
5. Summary of Data Reported and Evaluation
5.1 Experimental data
Carbazole was tested for carcinogenicity in mice by
administration in the diet, by skin application and by subcutaneous
injection. In the study by oral administration, a dose-dependent
increase in the incidence of liver neoplastic nodules and
hepatocellular carcinomas was observed. Papillomas and carcinomas of
the forestomach occurred in animals receiving the high-dose level.
The other studies in mice were considered inadequate for evaluation.
No data on the teratogenicity of this compound were available.
Carbazole was not mutagenic to Salmonella typhimurium.
There is inadequate evidence that carbazole is active in
short-term tests.
5.2 Human data
Carbazole is present as a major component of the total content of
polynuclear aromatic compounds in the environment, arising primarily
from the combustion of tobacco and coal.
5.3 Evaluation
There is limited evidence that carbazole is carcinogenic to
experimental animals.
For definition of the italicized terms, see Preamble Evaluation.
Subsequent evaluation: Vol. 71 (1999)
Synonyms
- 9-Azafluorene
- Dibenzopyrrole
- Dibenzo(b,d)pyrrole
- Diphenylenimine
Last updated: 13 April 1999