International Agency for Research on Cancer (IARC) - Summaries & Evaluations


VOL.: 32 (1983) (p. 269)

CAS No.: 27208-37-3
Chem. Abstr. Name: Cyclopenta(cd)pyrene

5. Summary of Data Reported and Evaluation

5.1 Experimental data

Cyclopenta[cd]pyrene was tested for carcinogenicity in two studies in female mice by skin application; it produced skin tumours in one study. It was also tested in the mouse-skin initiation-promotion assay in three studies and was active as an initiator.

No data were available on the teratogenicity of this chemical.

Cyclopenta[cd]pyrene was mutagenic to Salmonella typhimurium and to mammalian cells in vitro in the presence of an exogenous metabolic system. It induced morphological transformation in mammalian cells.

There is sufficient evidence that cyclopenta[cd]pyrene is active in short-term tests.

N.B. - Subsequent to the meeting, the Secretariat became aware of a study (Cavalieri et al., 1983) in which cyclopenta[cd]pyrene was tested alone or in combination with benzo[a]pyrene by repeated application to the skin of female Swiss mice. At the end of the experiment, analysis of the incidence of malignant skin tumours showed that the two compounds acted synergistically.

5.2 Human data

Cyclopenta[cd]pyrene is present as a minor component of the total content of polynuclear aromatic compounds in the environment but occurs as a major polynuclear aromatic component of gasoline engine exhaust.

N.B. - Studies on occupational exposure to polynuclear aromatic compounds will be considered in future IARC Monographs.

5.3 Evaluation

There is limited evidence that cyclopenta[cd]pyrene is carcinogenic to experimental animals.

For definition of the italicized terms, see Preamble Evaluation.

Subsequent evaluation: Suppl. 7 (1987) (p. 61: Group 3)


Last updated: 17 April 1998

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